Asthma and Children

2007-05-01T16:23:00.000+01:00

This review is a pragmatic attempt to highlight recent research and some backround reading in asthma and children. It should not be considered exhaustive, simply a way of reviewing some of the major developments and current thinking in the area.

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Evidence-Based Reports

Asthma and Other Wheezing Disorders in Children. Clinical Evidence, 2004
Beta-agonists with or without anti-cholinergics in the treatment of acute childhood asthma? BestBETS, 2006
Delivery of bronchodilators in acute asthma in children. BestBETS, 2006
Inhaled corticosteroids: children are at risk from high doses. MeReC, 2007
Use of x-rays in asthma. Paediatric Evidence Centre, 2006
Breath-a-tech vs Volumatic spacers. Paediatric Evidence Centre, 2006
Increased Doses of Inhaled Steroids During an Asthma Exacerbation Show No Benefit. Evidence-Based Pediatrics, 2005
Nebulized Magnesium Improves FEV1 in Mild to Moderate Asthma Exacerbations. Evidence-Based Pediatrics, 2005
Heliox May Prevent Hospital Admission for Asthma. Evidence-Based Pediatrics, 2006
Influenza Vaccine Efficacious Even for Asthmatic Children on Steroid Burst. Evidence-Based Pediatrics, 2006

Clinical Guidelines

Management of persistent asthma in infants and children 5 years of age and younger. Michigan Quality Improvement Consortium, 2006
Management of Acute Asthma in Children. Towards Optimised Practice, 2007
Pediatric asthma clinical practice guidelines. Kaiser Permanente Care Management Institute, 2006
Management of Asthma in Children aged 1-15 years. New Zealand Guidelines Group, 2005
Asthma. PRODIGY, 2007
Asthma Exemplar, National Service Framework for Children, Young People and Maternity Services, 2004

Systematic Reviews

Long-acting beta2-agonists for chronic asthma in adults and children where background therapy contains varied or no inhaled corticosteroid. Cochrane Database of Systematic Reviews, 2007
Asthma Attack - Targeting Emergency Asthma Contacts in Children. NHS Quality Improvement Scotland, 2006
A systematic review to examine the impact of psycho-educational interventions on health outcomes and costs in adults and children with difficult asthma. NCCHTA, 2005
Family therapy for chronic asthma in children. Cochrane Database of Systematic Reviews, 2005
Psychological interventions for children with asthma. Cochrane Database of Systematic Reviews, 2005
Long-acting beta2-agonists as an inhaled corticosteroid-sparing agent for chronic asthma in adults and children. Cochrane Database of Systematic Reviews, 2005
Fluticasone at different doses for chronic asthma in adults and children. Cochrane Database of Systematic Reviews, 2005
Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators. Cochrane Database of Systematic Reviews, 2005
Oral xanthines as maintenance treatment for asthma in children. Cochrane Database of Systematic Reviews, 2005
Written action plans for asthma in children. Cochrane Database of Systematic Reviews, 2006
Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma. Cochrane Database of Systematic Reviews, 2006
Nedocromil sodium for chronic asthma in children. Cochrane Database of Systematic Reviews, 2006
Anti-IgE for chronic asthma in adults and children. Cochrane Database of Systematic Reviews, 2006
Cost-effectiveness of early intervention with once-daily budesonide in children with mild persistent asthma: results from the START study. NHS EED, 2006

Recent articles in core journals

Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial. J Allergy Clin Immunol, 2007
Internet-based home monitoring and education of children with asthma is comparable to ideal office-based care: results of a 1-year asthma in-home monitoring trial. Pediatrics, 2007
Short-course montelukast for intermittent asthma in children: a randomized controlled trial. Am J Respir Crit Care Med, 2007
Effectiveness of nebulizer use-targeted asthma education on underserved children with asthma. Arch Pediatr Adolesc Med, 2006
Effects of treatment with mometasone furoate dry powder inhaler in children with persistent asthma. Ann Allergy Asthma Immunol, 2006
Improved asthma outcomes in a high-morbidity pediatric population: results of an emergency department-based randomized clinical trial. Arch Pediatr Adolesc Med, 2006
An interdisciplinary intervention for undertreated pediatric asthma. Chest, 2006
A randomized, controlled trial of an interactive educational computer package for children with asthma. Pediatrics, 2006
A randomized clinical trial of clinician feedback to improve quality of care for inner-city children with asthma. Pediatrics, 2006
Once-daily ciclesonide in children: efficacy and safety in asthma. J Pediatr, 2006
Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysis. Chest, 2006
Oral montelukast treatment of preschool-aged children with acute asthma. Ann Allergy Asthma Immunol, 2006
Budesonide/Formoterol Maintenance Plus Reliever Therapy: A New Strategy in Pediatric Asthma. Chest, 2006
Long-term inhaled corticosteroids in preschool children at high risk for asthma. NEJM, 2006
Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet, 2006
Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol, 2006
Efficacy and safety of inhaled fluticasone propionate chlorofluorocarbon in 2- to 4-year-old patients with asthma: results of a double-blind, placebo-controlled study. Ann Allergy Asthma Immunol, 2006
Linear growth in prepubertal asthmatic children treated with montelukast, beclomethasone, or placebo: a 56-week randomized double-blind study. Ann Allergy Asthma Immunol, 2006

eTextbooks

Clinical Queries

Are overweight or obese children who wheeze more likely to be diagnosed with asthma than non-obese children? NLH Q&A Service, 2006 View answer OR Can you answer this question for extra CPD?
What is the optimum dose and duration of treatment with oral steroids for an acute exacerbation of asthma in an otherwise healthy adult / child? NLH Q&A Service, 2007
Is it reasonable to advise short-term use of ibuprofen in feverish children with h/o of asthma? NLH Q&A Service, 2006 View answer OR Can you answer this question for extra CPD?
Parents often suggest that sleeping in damp bedrooms or living in damp housing causes or exacerbates their child's asthma. Is there any evidence that this is true? NLH Q&A Service, 2006
Is there any evidence to suggest a link between paracetamol and asthma or wheezing in children or paracetamol taken in pregnancy and wheezing? NLH Q&A Service, 2005 View answer OR Can you answer this question for extra CPD?

Patient Information

BUPA Health Information
Better Health Channel
eMedicine Consumer Health
Family Doctor
NHS Direct
Inhaler Technique. Builth Surgery (YouTube, online video)
Spacer Devices part 1. Builth Surgery (YouTube, online video)
Spacer Devices part 2. Builth Surgery (YouTube, online video)

TRIP Evidence Reviews: Asthma and Children

Asthma and Children